Comment Re: My mask your mask (Score 1) 146
There were 9,162,484 noninstitutionalized adult Florida residents who met inclusion criteria, including 5,328,226 BNT162b2 vaccine recipients and 3,834,258 mRNA-1273 vaccine recipients. A total of 1,470,100 vaccinees were matched 1-to-1 based on seven criteria, including census tract. Compared with mRNA-1273 recipients, BNT162b2 recipients had significantly higher risk for all-cause mortality (847.2 vs. 617.9 deaths per 100,000; odds ratio, OR [95% CI]: 1.384 [1.331, 1.439]), cardiovascular mortality (248.7 vs. 162.4 deaths per 100,000 persons; OR [95% CI]: 1.540 [1.431,1.657]), COVID-19 mortality (55.5 vs. 29.5 deaths per 100,000 persons; OR [95% CI]: 1.882 [1.596, 2.220]) and non-COVID-19 mortality (791.6 vs. 588.4 deaths per 100,000 persons; OR [95% CI]: 1.356 [1.303, 1.412]). Negative control outcomes did not show any indication of meaningful unobserved residual confounding.
The risk of COVID-19 mortality was higher in BNT162b2 recipients compared to mRNA-1273 recipients (OR [95% CI]: 1.882 [1.596, 2.220]), with an excess per 100,000 persons of 26.0 deaths (95% CI: [19.3, 32.6]). The corresponding risk ratio was 1.88 (95% CI: [1.59, 2.22]). Non-COVID-19 mortality risk was also higher in BNT162b2 recipients compared to mRNA-1273 recipients (OR [95% CI]: 1.356 [1.303, 1.412]), with an excess per 100,000 persons of 203.3 deaths (95% CI: [176.5, 230.0]). This corresponded with a risk ratio of 1.35 (95% CI: [1.29, 1.40])